About
A manufacturer specializing in filtration and separation materials, founded in Hangzhou in 2003. It produces in-house the entire fluid path of biopharmaceutical processes, from sterilizing filtration and virus removal filters, depth filters, and TFF cassettes and hollow fibers to single-use bags and assemblies and integrity testers. It has overseas subsidiaries in Japan, Korea, Taiwan and Singapore.
Products
Product Lines
Filtration & Separation
- Viruclear™ virus removal filters
- Roheap™ CSD depth filters
- TFF cassettes · hollow fiber filters
- Sterilizing-grade liquid filters (PES · PVDF) · gas filters
- Membrane chromatography
- Syringe filters · centrifugal filters (for laboratory use)
Fluid Management (Single-Use)
- Lifecask™ RG single-use bioreactor bags
- Lifecube™ single-use assemblies
- 2D · 3D bags, tubing · connector assemblies
- Aseptic filling assemblies · PUPSIT
Filtration Equipment
- Biophsep™ MiniLab TFF system
- Certitest™ filter integrity tester
Fluid Management Equipment
- Convemate™ 4-piston diaphragm pump
- Lifemeta™ tube welder · sealer
How to choose
Product Selection Information
Main Uses
- Sterilizing-grade filtration of process liquids
- Sterilizing-grade filtration of gas lines (gas filter series)
- Laboratory-scale filtration (syringe filters · centrifugal filters)
Selection Criteria
- Fluid: media · buffers · intermediates · final bulk; liquid or gas
- Membrane material and its chemical compatibility with the fluid · adsorption characteristics
- Size and format: specifications matched to throughput and installation method
- Sterilization method and integrity test method
- Technical documents to request: validation guides · extractables data · certificates of analysis
Confirmed Specifications & Options
- Membrane materials for liquids: PES · PVDF
- Product series for liquids: DPSTF(PES) · DLHPVDF/LHPVDF · APSBR · SPSHR
- Sterilizing-grade series for gases: DGPFMP/GPFMP · HSGPFP
- For laboratory use: syringe filters · centrifugal filters
What to Tell Us
- Type and composition of the fluid to be filtered
- Throughput per batch and target filtration time
- Process stage and sterilization method
- Filter and housing specifications currently in use
- Scope of technical documentation needed
Cobetter · Filtration & Separation
TFF Cassettes · Hollow Fiber Filters
Main Uses
- Cassettes and hollow fiber filters for tangential flow filtration (TFF) processes
- Laboratory-scale TFF (Biophsep™ MiniLab TFF system)
Selection Criteria
- Format: cassette or hollow fiber
- Size of the target substance and the matching molecular weight cut-off · pore size
- Membrane material and the target substance's adsorption · shear sensitivity
- Membrane area: based on throughput and process time
- Fit compatibility with existing holders and systems
Confirmed Specifications & Options
- Formats: TFF cassettes · hollow fiber filters
- Related equipment: Biophsep™ MiniLab TFF system
What to Tell Us
- Type and molecular weight · size of the target substance
- Process volume, target concentration factor and number of diafiltration exchanges
- TFF system · holder currently in use
- Specifications of the membrane currently in use
- Process scale: laboratory · pilot · production
Cobetter · Filtration & Separation
Virus Removal Filters (Viruclear)
Main Uses
- Virus removal filtration step in biopharmaceutical processes
- Viruclear™ virus removal filter series
Selection Criteria
- Target product: protein type · concentration · buffer composition
- Size range of the viruses to be removed
- Whether prefiltration (a prefilter) is needed
- Scale: from small formats for process development to production sizes
- Technical documents to request: virus removal study data · integrity test method
Confirmed Specifications & Options
- Product series: Viruclear™ virus removal filters
What to Tell Us
- Type · concentration · buffer composition of the target product
- Throughput per batch and target process time
- Virus filter currently in use
- Virus removal validation plan · schedule
- Process stage: development · clinical · commercial production
Cobetter · Single-Use & Fluid Management
Single-Use Bags · Assemblies
Main Uses
- Single-use bioreactor bags
- 2D · 3D bags and tubing · connector assemblies
- Aseptic filling assemblies · PUPSIT configurations
Selection Criteria
- Use: storage · transfer · culture · filling
- Volume and format: 2D or 3D
- Port · tubing · connector · filter configuration
- Compatibility of fluid-contact materials with the process fluid
- Documents to request: extractables · sterilization · integrity data
Confirmed Specifications & Options
- Lifecask™ RG single-use bioreactor bags
- Lifecube™ single-use assemblies
- 2D · 3D bags
- Tubing · connector assemblies
- Aseptic filling assemblies · PUPSIT
What to Tell Us
- Use and process stage
- Volume and quantity needed
- Connection method: tubing size · connector type
- Drawings, or the assembly configuration currently in use
- Scope of quality documentation needed